LATEST - Farmed Salmon Lack of oversight report .
The files on this page are suitable for working with MP's, investors and business. They show the science that is animal free, market and potential of the growth and management of animal free research (December 2025) These files will be updated regularly. They include a chamber of commerce action plan and summary, comparison charts with the costs of animals used scientific rationale.
Reliance on AF methods in drug development (jpg)
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No, the process of animal testing has not been rigorously or universally scientifically validated as reliably predictive of human outcomes. While animal models are historically required by regulators, extensive scientific literature shows that they often fail to accurately predict human responses, with high failure rates (around 90%) of drugs passing animal tests but failing in human trials due to safety or efficacy issues. Critics highlight that many common animal tests lack formal validation against human data and demonstrate poor overall predictive validity across disease areas.
Several specific areas of animal testing have been fully or largely replaced by validated non-animal alternatives, particularly in regulatory safety testing. Examples include skin corrosion and irritation (replaced by reconstructed human skin models like EpiSkin or EpiDerm), eye irritation (phased out in many cases with in vitro methods), skin sensitization (using defined approaches and cell-based assays), and certain vaccine potency or batch safety tests (e.g., cell culture methods replacing animal challenge tests for some vaccines like yellow fever or rabies). The rabbit pyrogen test for fever-causing contaminants has also been phased out in favor of cell-based monocyte activation tests in many pharmacopoeial standards.
n drug development, certain preclinical toxicity tests—like skin sensitization (using cell-based assays) and eye irritation (via in vitro models)—have been fully supplanted, and the FDA is actively phasing out animal testing requirements for monoclonal antibodies and some biologics, favoring alternatives like organ-on-chips, organoids, and AI-driven models. Stem cell research has largely shifted to human-induced pluripotent stem cells (iPSCs) and organoids for in vitro disease modeling, drug screening, and regenerative studies, eliminating routine animal use in these applications. Other examples include medical training, where human-patient simulators have replaced live animals for surgical skills in most countries and vaccine production techniques, such as polio vaccines now using human cell cultures instead of monkey kidney cells. Overall, non-animal methods are increasingly dominant in these targeted areas